(HealthDay News) – Vitamin D may influence atopic dermatitis, and supplementation is associated with reduced disease severity, according to a study published in the August issue of the Journal of the American Academy of Dermatology.
Zbigniew Samochocki, MD, PhD, from the Medical University of Warsaw in Poland, and colleagues examined the correlation between vitamin D concentrations and clinical, immunologic, constitutional, and environmental factors in a cohort of 95 patients with atopic dermatitis and 58 controls. Atopic dermatitis severity was measured using the scoring atopic dermatitis (SCORAD) index.
The researchers observed no significant difference with respect to the mean serum concentration of 25-hydroxyvitamin D3 (25[OH]D3) for patients with atopic dermatitis and controls. Patients with atopic dermatitis who had lower 25(OH)D3 levels had a higher frequency of bacterial skin infections. No significant correlations were identified for vitamin D levels with other laboratory and clinical parameters. The mean objective SCORAD and SCORAD index were significantly lower after supplementation.
“In conclusion, vitamin D may influence the course of atopic dermatitis,” the authors write. “The results from this study indicate that vitamin D supplementation may ameliorate clinical signs of the disease and can be considered as a safe and well-tolerated form of therapy.”