(HealthDay News) – Computed tomography (CT) colonography is useful as a primary screening method for detecting colorectal neoplasia in adults over the age of 65 years, with sensitivity and specificity similar to that seen for younger adults, according to research published online Feb. 23 in Radiology.

C. Daniel Johnson, MD, of the Mayo Clinic in Scottsdale, AZ, and colleagues conducted a post-hoc analysis of National CT Colonography Trial data involving 2,600 asymptomatic subjects, 497 of whom were ≥65 years of age, to compare the specificity and sensitivity of CT colonography for older and younger participants. The primary end point was the ability to detect histologically confirmed colorectal neoplasia that were 10mm or larger in diameter.

The researchers found that adenomas 1cm or larger were present in 6.9% of the 477 older patients who had complete data available, compared with 3.7% of participants aged 50–65 years. There were no statistically significant differences in the accuracy of CT colonography for the detection of large and intermediate-sized colorectal neoplasia between older and younger patients. For large neoplasms, the sensitivity and specificity were 0.82 and 0.83, respectively, for older patients and 0.92 and 0.86, respectively, for younger patients.

“In summary, a post-hoc analysis of data from the National CT Colonography Trial did not find significant differences in the diagnostic accuracy of CT colonography for the detection of large and intermediate-size adenomatous lesions in participants 65 years of age and older compared with younger participants,” the authors write.

Full Text (subscription or payment may be required)