(HealthDay News) — Patients with allergy to Glupearl 19S, an acid-hydrolyzed wheat protein (HWP), often manifest symptoms of HWP-wheat-dependent exercise-induced anaphylaxis and contact urticaria, according to a report published online June 20 in the International Journal of Dermatology.

Tomoko Kobayashi, MD, from Tokyo Medical University, and colleagues describe 61 cases of patients who had used HWP-containing facial soap. After consuming wheat-containing food, 35 of these patients experienced urticaria or anaphylaxis.

The researchers found that 18 of the 35 patients with urticaria or anaphylaxis tested positive to 0.01% Glupearl 19S solution. In patients with vs. without HWP allergy, wheat-specific immunoglobulin E (IgE) and serum gluten-specific IgE were elevated. Nine of the patients who tested positive to Glupearl 19S on the skin-prick test experienced HWP-wheat-dependent exercise-induced anaphylaxis and four experienced food-dependent anaphylaxis. Furthermore, four patients experienced worsening of symptoms during exercise in addition to food-dependent anaphylaxis.

“We found that patients with HWP allergy tended to manifest symptoms of both HWP-wheat-dependent exercise-induced anaphylaxis and contact urticaria,” the authors write. “Patients with a history of these symptoms need to be informed about the risk of consuming wheat-containing foods and the importance of excluding such items from their diet.”

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