(HealthDay News) – A high urinary albumin-to-creatinine ratio at baseline is associated with a higher risk of a first coronary heart disease (CHD) event in blacks compared with whites, with no racial differences in the risk of a recurrent CHD event, according to a study published in the Aug. 21 issue of the Journal of the American Medical Association.
Orlando M. Gutierrez, MD, MMSc, from the University of Alabama at Birmingham, and colleagues examined the association between the urinary albumin-to-creatinine ratio and the risk of CHD based on race in two groups: incident CHD among 23,273 participants without CHD at baseline, and first recurrent CHD event among 4,934 participants with CHD at baseline.
Over a median of 4.4 years of follow-up, the researchers noted 616 incident CHD events and 468 recurrent CHD events. After adjusting for several factors, a higher urinary albumin-to-creatinine ratio at baseline was associated with a significantly higher risk of incident CHD among black subjects (hazard ratio [HR], 3.21 for highest vs. lowest ratio) but not white subjects (HR, 1.49). In contrast, there were no differences in the risk of recurrent CHD among blacks (HR, 2.21) and whites (HR, 2.48).
“Higher urinary albumin-to-creatinine ratio was associated with greater risk of incident but not recurrent CHD in black individuals when compared with white individuals,” Gutierrez and colleagues conclude.
Several authors disclosed financial relationships with pharmaceutical companies, including Amgen, which partly funded the study.