(HealthDay News) – Testosterone supplementation is associated with improved exercise capacity in patients with moderate-to-severe heart failure.
To assess the effects of testosterone supplementation on exercise capacity, Mustafa Toma, MD, of the University of British Columbia in Vancouver, Canada, and colleagues conducted a meta-analysis of the literature based on four randomized trials involving 198 patients (84% men; average age 67 years) with moderate-to-severe heart failure.
The researchers found that, compared with placebo, testosterone therapy was associated with a significant improvement in exercise capacity, including mean increases in the six-minute walk test (54m), incremental shuttle walk test (46.7m), and peak maximal oxygen consumption (2.7mL/kg/min). There were no significant adverse cardiovascular events reported.
“Testosterone is a promising therapy to improve exercise capacity in heart failure patients,” the authors write. “Adequately powered randomized controlled trials are now required to assess the benefits of testosterone in this high-risk population assessing quality of life, clinical events, and safety.”
Two of the authors disclosed receiving funding from Alberta Innovates – Health Solutions.