Background & Aims: Statins have been associated with a reduced risk of esophageal adenocarcinoma, but little is known about their effect on development of Barrett’s esophagus. We evaluated the association between statins and risk of Barrett’s esophagus. Methods: We conducted a case-control study among eligible patients scheduled for elective esophagogastroduodenoscopy and patients eligible for screening colonoscopy, recruited from primary care clinics at a Veterans Affairs center.