(HealthDay News) – For patients admitted with acute coronary syndrome, a personalized attention and coordinated care intervention involving a pharmacist is associated with improved medication adherence after discharge, according to a study published Nov. 18 in JAMA Internal Medicine.

P. Michael Ho, MD, PhD, from the VA Eastern Colorado Health Care System in Denver, and colleagues randomized patients with acute coronary syndrome from four Department of Veterans Affairs medical centers to a multifaceted intervention (INT; 122 patients) or usual care (UC; 119 patients) prior to discharge. The INT, which lasted for one year after discharge, included pharmacist-led medication reconciliation and tailoring; patient education; collaborative care; and educational and medication refill reminder calls.

The researchers found that significantly more patients were adherent in the INT vs. the UC group (89.3% vs. 73.9%, respectively; P=0.003). The INT group had a higher mean proportion of days covered (0.94 vs. 0.87; P<0.001). Adherence was significantly greater among INT patients for clopidogrel (86.8% vs. 70.7%; P=0.03), statins (93.2% vs. 71.3%; P<0.001), and angiotensin-converting enzyme inhibitors or angiotensin receptor blockers (93.1% vs. 81.7%; P=0.03), but not for β-blockers (88.1% vs. 84.8%; P=0.59).

“Understanding the impact of such improvement in adherence on clinical outcomes is needed prior to broader dissemination of the program,” the authors write.

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