(HealthDay News) – An eye test measuring ocular pulse amplitude (OPA) can be performed by ophthalmologists to detect severe carotid artery stenosis (CAS), a known risk factor for stroke.

Pascal B. Knecht, MD, from the University Hospital of Zurich, and colleagues used dynamic contour tonometry to measure the OPA on both eyes of 42 men and 25 women (mean age, 67 years) and evaluate its accuracy as a screening test for CAS.

The researchers found that the means of the OPA values differed significantly in patients with no CAS (<50% blockage) compared to patients with severe stenosis (>70% blockage) (P=0.036). A multivariate analysis, using risk factors for CAS, including age, total cholesterol, low-density lipoprotein, and triglycerides, showed a statistically significant odds ratio for the ability of downstream OPA measurements to predict CAS of >70% (odds ratio, 0.46; P=0.007).

“The results of the present study provide proof of principle that the OPA is reduced in patients with CAS and may be used as a noninvasive, inexpensive, readily available, and unconfounded screening parameter to detect CAS and possibly to reduce the incidence of stroke,” the authors conclude.

Continue Reading

Full Text (subscription or payment may be required)