(HealthDay News) – Greater sedentary time is associated with increased risk of diabetes, cardiovascular disease, and cardiovascular and all-cause mortality, with the most consistent associations seen for diabetes, according to a review and meta-analysis published in the November issue of Diabetologia.

Emma G. Wilmot, M.B., Ch.B., from the University of Leicester in the United Kingdom, and colleagues conducted a literature review and meta-analysis to examine the correlation of sedentary time with diabetes, cardiovascular disease, and cardiovascular and all-cause mortality. Using a random-effects model, data were pooled from 18 studies (16 prospective and two cross-sectional) involving 794,577 participants. Fifteen studies were of a moderate to high quality.

The researchers found that the greatest compared with the lowest sedentary time correlated with a significant increase in the relative risk (RR) of diabetes (RR, 2.12) and cardiovascular events (RR, 2.47), as well as a significant increase in the risk of cardiovascular (hazard ratio, 1.90) and all-cause mortality (hazard ratio, 1.49). Only for diabetes were the predictive effects and intervals significant.

“In conclusion, the findings of this meta-analysis have important implications for future research and public health guidance,” the authors write. “There is an urgent need to further investigate the impact of reducing sedentary time on metabolic health.”

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