(HealthDay News) – Prehypertension, especially high-range prehypertension, is associated with an increased risk of coronary heart disease (CHD), according to a meta-analysis published in the July 15 issue of The American Journal of Cardiology.

Li Shen, PhD, from Zhejiang University in Hangzhou, China, and colleagues conducted a meta-analysis of prospective cohort studies to examine the correlation between baseline prehypertension and the risk for CHD. Eighteen studies were included, with a median follow-up period of 8.8 years, which consisted of 934,106 participants and 14,952 cases.

The researchers found that prehypertension correlated with a significantly increased risk of CHD (relative risk, 1.36). Risk estimates were further classified into low-range (120/80–129/84mmHg) and high-range prehypertension (130/85–139/89mmHg) in eight studies comprising 12 cohorts. High-range prehypertension (relative risk, 1.53), but not low-range prehypertension (relative risk, 1.16; P=0.019) correlated with a significantly increased risk of CHD.

“In conclusion, prehypertension is associated with a significantly increased risk for developing CHD, particularly high-range prehypertension,” the authors write. “Further well-designed randomized controlled trials are needed to clarify the efficacy of blood pressure reduction in subjects with prehypertension.”

Full Text (subscription or payment may be required)