Data Sources: Multiple electronic databases between January 2007 and April 2014, without language restriction. Nine head-to-head trials showed greater pain reduction associated with serotonin-norepinephrine reuptake inhibitors (SNRIs) than anticonvulsants (standardized mean difference [SMD], 0.34 [95% credible interval {CrI}, 0.63 to 0.05]) and with tricyclic antidepressants (TCAs) than topical capsaicin 0.075%.

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