HealthDay News — Soy intake may modify the association between bisphenol A (BPA) and fertility in women undergoing assisted reproduction, according to research published online January 27 in the Journal of Clinical Endocrinology & Metabolism.

Jorge E. Chavarro, MD, ScD, of Harvard University in Boston, and colleagues conducted a prospective cohort study of 239 women who underwent 347 in vitro fertilization (IVF) cycles. The effect of soy consumption on the relation between urinary BPA levels and infertility treatment outcomes was examined.

The researchers found that the association of urinary BPA concentration with live birth rates per initiated treatment cycle was modified by soy food consumption. The adjusted live birth rates per initiated treatment cycle, in increasing quartiles of cycle-specific urinary BPA concentrations, were 54, 35, 31, and 17% (P for trend = 0.03) among women who did not consume soy foods, and 38, 42, 47, and 49% (P for trend = 0.35) among women who reported that they consumed soy foods prior to treatment.

“Soy food intake may protect against the adverse reproductive effects of BPA,” the authors write. “As these findings represent the first report suggesting a potential interaction between soy and BPA in humans, they should be further evaluated in other populations.”

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