(HealthDay News) – Moderate or severe psoriasis is associated with chronic kidney disease, according to a study published online Oct. 15 in BMJ.

Joy Wan, MD, from the University of Pennsylvania in Philadelphia, and colleagues conducted a population-based cohort study and a nested cross-sectional study to examine the risk of chronic kidney disease in patients with psoriasis. A total of 136,529 patients with mild psoriasis and 7,354 patients with severe psoriasis were matched to 689,702 unaffected patients in the cohort study. The nested study included 8,731 patients with psoriasis matched to 87,310 patients without psoriasis.

The researchers found that, in the cohort study, the adjusted hazard ratios for incident chronic kidney disease were 1.05 in the overall psoriasis group, 0.99 for mild psoriasis, and 1.93 for severe psoriasis. In the severe psoriasis group, age was a significant effect modifier, with age-adjusted hazard ratios of 3.82 for patients aged 30 years and 2 for those aged 60 years. In the nested analysis, the adjusted odds ratios for chronic kidney disease were 0.89 for mild psoriasis, 1.36 for moderate psoriasis, and 1.58 for severe psoriasis.

“Future studies are warranted to confirm our findings, determine the mechanisms mediating renal insufficiency in psoriasis, and examine the impact of treatment for psoriasis on the risk of chronic kidney disease,” the authors write.

Two authors disclosed financial ties to the pharmaceutical industry.

Full Text