Olanzapine/Fluoxetine Combination vs. Fluoxetine Monotherapy in Treatment-Resistant Depression

This study assessed prevention of relapse in patients with treatment-resistant depression (TRD) taking olanzapine/fluoxetine combination (OFC). Patients with major depressive disorder (MDD) who failed to satisfactorily respond to 2 different antidepressants for 6 weeks within the current MDD episode were acutely treated for 6–8 weeks, followed by stabilization (12 weeks) on OFC.

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