(HealthDay News) — Dermal injection of cosmetic fillers into the forehead can lead to irreversible blindness, according to a study published in the May issue of JAMA Ophthalmology.

Michelle V. Carle, MD, from the Retina-Vitreous Associates Medical Group in Los Angeles, and colleagues describe irreversible vision loss from central retinal occlusion occurring after cosmetic facial enhancement.

The authors note that although cosmetic facial fillers are not approved for use in the forehead, they are frequently used off-label for enhancement in this region. No prior reports of blindness cause by filler injected into the forehead have been published. Three cases of central retinal artery occlusion due to fillers were reported shortly after cosmetic procedures, with the assumption that the filler enters the central retinal artery via the external-internal carotid anastomoses and becomes embedded in the retinal tissues. One patient had a small amount of recovery after aggressive therapy.

“Physicians performing cosmetic enhancement procedures involving facial fillers need to be aware of this potential complication and should include significant vision loss as a possible rare complication,” the authors write.

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