(HealthDay News) — Individuals with a history of nonmelanoma skin cancer (NMSC) have an increased risk of subsequent primary cancers, according to a study published in the March issue of Cancer Epidemiology, Biomarkers & Prevention.

Eugene Liat Hui Ong, BMBCh, from the University of Oxford in the United Kingdom, and colleagues used data from an all-England record-linked hospital and mortality dataset from 1999–2011 to examine the risk of primary malignant cancers in individuals with a history of NMSC. Two cohorts were constructed: one including 502,490 people with a history of NMSC and a second that included people without a history of NMSC. The cohorts were followed electronically to ascertain the observed and expected numbers of people with subsequent primary cancers.

The researchers found that the standardized relative risk for all subsequent malignant cancers was 1.36 for the NMSC cohort versus the non-NMSC cohort. For 26 of the 29 cancer types studied, the relative risks were significantly increased (P<0.05), in particular for salivary gland, melanoma, bone, and upper gastrointestinal tract cancers. Younger people with versus those without NMSC had particularly high relative risks.

“NMSC is strongly associated with a broad spectrum of other primary cancers, particularly in younger age groups,” the authors write. “The pattern suggests a genetic or early-acquired etiologic association.”

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