(HealthDay News) – Postmenopausal hormone levels are not generally associated with cognition or mood, according to a study published online Nov. 25 in the Proceedings of the National Academy of Sciences.

Victor W. Henderson, MD, from Stanford University in California, and colleagues examined the association between serum levels of sex hormones (free estradiol, estrone, progesterone, free testosterone, and sex hormone binding globulin) and cognition and mood in 643 healthy postmenopausal women not using hormone therapy. Subjects were either in early menopause (<6 years) or late menopause (≥10 years).

The researchers found that, overall, hormone levels were not associated with verbal memory, executive function, global cognition, or mood in either early or late menopause. However, sex hormone binding globulin levels were associated with improved verbal memory, and progesterone levels were associated with improved verbal memory and global cognition in early menopause.

“Physiological variations in endogenous postmenopausal levels of sex steroid hormones are not substantially related to these aspects of cognition or mood; positive associations for progesterone and sex hormone binding globulin merit additional study,” Henderson and colleagues conclude.

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