Monitoring Direct Thrombin Inhibitors: aPTT or Alternative?

Objectives: The activated partial thromboplastin time (aPTT) test has been used for years to monitor parenteral direct thrombin inhibitors (DTIs) and unfractionated heparin. Results: The aPTT correlated poorly with each of the other tests in both bivalirudin- and argatroban-containing samples (r2 = 0.04-0.23).

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