(HealthDay News) – Even metabolically healthy obese are at increased risk of all-cause mortality and/or cardiovascular events, according to a review published in the Dec. 3 issue of the Annals of Internal Medicine.
Caroline K. Kramer, MD, PhD, from the University of Toronto, and colleagues examined the effect of metabolic status on all-cause mortality and cardiovascular events in normal-weight, overweight, and obese individuals in a meta-analysis of eight studies involving 61,386 individuals and 3,988 events.
Based on studies with ≥10 years of follow-up, the researchers found that the risk of events was significantly increased among metabolically healthy obese (relative risk [RR], 1.24), compared with metabolically healthy normal-weight individuals. A similarly elevated risk was seen for all metabolically unhealthy groups: normal-weight (RR, 3.14), overweight (RR, 2.7), and obese (RR, 2.65).
“Compared with metabolically healthy normal-weight individuals, obese persons are at increased risk for adverse long-term outcomes even in the absence of metabolic abnormalities, suggesting that there is no healthy pattern of increased weight,” the authors write.