(HealthDay News) – For women with mild traumatic brain injury (mTBI), one-month quality-of-life and neurologic outcomes are influenced by menstrual cycle phase and progesterone concentration at the time of injury, according to a study published online Nov. 11 in the Journal of Head Trauma Rehabilitation.

Kathryn Wunderle, from the University of Rochester in New York, and colleagues conducted a nested cohort study in six emergency departments to examine the impact of menstrual cycle phase in women at the time of mTBI on one-month neurologic and quality-of-life outcomes. Participants included 144 females (aged 16–60 years) who presented to emergency departments within four hours of mTBI.

The researchers found that the EuroQoL General Health Ratings and Index Scores were significantly lower for women injured during the luteal phase of their menstrual cycle (high progesterone concentration) than for women injured during the follicular phase of their cycle or among women taking oral contraceptives. The significant independent effect of menstrual cycle phase on EuroQoL Index Score and the Rivermead Post Concussion Questionnaire Somatic Subscore was confirmed in multivariate analysis.

“Menstrual cycle phase and progesterone concentration at the time of mTBI affect one-month quality-of-life and neurologic outcomes,” the authors conclude. “This association has important implications for treatment and prognosis after mTBI.”

One author disclosed financial ties to the diagnostic industry.

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