(HealthDay News) — People with low blood levels of vitamin D are twice as likely to die prematurely, according to a review published online June 12 in the American Journal of Public Health.

Cedric F. Garland, DrPH, from the University of California in San Diego, and colleagues conducted a literature review to identify studies that examine the relationship between serum 25-hydroxyvitamin D (25[OH]D) and all-cause mortality.

The researchers found, based on pooled data from 32 studies, that the hazard ratio for all-cause mortality was 1.9 (P<0.001) when comparing the lowest (0–9 nanograms per milliliter [ng/mL]) to the highest (>30ng/mL) category of 25(OH)D. There was an association between serum 25(OH)D concentrations ≤30ng/mL and higher all-cause mortality, compared to concentrations >30 g/mL (P<0.01).

“Our findings agree with a National Academy of Sciences report, except the cutoff point for all-cause mortality reduction in this analysis was >30ng/mL rather than >20ng/mL,” the authors write.

One author disclosed receiving funding from councils or organizations involved with promoting vitamin D studies.

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