Taliha Öner, MD, from Dr. Behçet Uz Children’s Hospital in Izmir, Turkey, and colleagues examined the correlation between vitamin B12 levels and POTS during adolescence. Serum vitamin B12, folic acid, and ferritin levels were assessed in 125 patients (mean age, 11.1 years; 60% female) reporting short-term loss of consciousness and diagnosed with vasovagal syncope, and 50 control subjects (mean age, 10.94 years; 62% female).
The researchers found that patients had significantly lower levels of vitamin B12 vs. controls (352.75 vs. 411.32pg/mL; P<0.001), and that a low vitamin B12 level was significantly more prevalent in the patient vs. the control group (47.2 vs. 18%; P<0.001). Within the patient group, vitamin B12 levels were significantly lower in children with the POTS pattern than those without the POTS response (P=0.03).
“Our study shows the association between the etiopathogenesis of POTS and the vitamin B12 deficiency-induced sympathetic nervous system-baroreceptor dysfunction,” the authors write.