HealthDay News — For patients with atrial fibrillation (AF) and left ventricular systolic dysfunction, cardiomyopathy etiology impacts long term outcomes of catheter ablation, according to a study published online December 28 in the Journal of Cardiovascular Electrophysiology.

Sandeep Prabhu, MBBS, from Alfred Hospital in Melbourne, Australia, and colleagues examined the impact of cardiomyopathy etiology on long-term outcomes following catheter ablation for AF. Participants included 101 patients with known heart disease as a cause of cardiomyopathy (KHD; 77 patients) and idiopathic dilated cardiomyopathy (IDCM; 24 patients). The patients had left ventricular ejection fraction (LVEF) <45% and underwent AF ablation from 2002 to 2014.

The researchers found that AF control was greater in the IDCM group after a mean follow-up of 36 ± 23 months (82%, versus 50% in KHD; P < 0.01). IDCM correlated with long-term AF control on multivariate analysis (P = 0.033). At follow-up, the IDCM group had less functional impairment (P = 0.005) and improved LVEF (P < 0.001). Super responders, with EF improvement of more than 15 percent, were mainly found in the IDCM group (94 versus 6%; P < 0.001), with greater AF control (89 versus 61%; P < 0.001). The KHD group had significantly higher all-cause mortality (17 versus 1.3%; P = 0.002).

“IDCM was associated with greater AF control, and improvement in symptoms and LVEF compared to patients with KHD post AF ablation,” the authors write.

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One author disclosed financial ties to the medical device and medical technology industries.

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