(HealthDay News) – Adults with low levels of 25-hydroxyvitamin D (25[OH]D) have increased mortality, regardless of the presence of estimated glomerular filtration rate (eGFR) of <60mL/min/1.73m².

Holly Kramer, MD, MPH, from the Loyola University Medical Center in Maywood, Ill., and colleagues examined all-cause mortality rates across 25(OH)D levels over an 18-year follow-up period for adults stratified according to their eGFR. Participants included 1,097 U.S. adults with eGFR <60mL/min/1.73m² and 14,002 with an eGFR ≥60mL/min/1.73m².

The researchers found that, for adults with eGFR <60mL/min/1.73m², the prevalence of 25(OH)D levels <30ng/mL was 76.5% and the prevalence of 25(OH)D levels <20ng/mL was 35.4%. The corresponding prevalences among adults with eGFR ≥60mL/min/1.73m² were 70.5 and 30.3%. After adjustment for covariables, including comorbid conditions, individuals with 25(OH)D levels <12ng/mL had significantly higher mortality rates compared to those with levels of 24–<30ng/mL, with a rate ratio of 1.41 for those with eGFR <60mL/min/1.73m² and 1.32 for those with eGFR ≥60mL/min/1.73m². After adjustment for all covariates, mortality rates were fairly similar across all 25(OH)D groups with levels >20ng/mL.

“In conclusion, while significantly higher mortality rates are noted with 25(OH)D levels <12ng/mL, mortality rates are fairly similar across the range of 25(OH)D levels 20–40 ng/mL among adults with and without eGFR <60mL/min/1.73m²,” the authors write.

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