(HealthDay News) – Among women, a history of kidney stones is associated with an increased risk of coronary heart disease (CHD), according to a study published in the July 24/31 issue of the Journal of the American Medical Association.

Pietro Manuel Ferraro, MD, from the Columbus-Gemelli Hospital in Rome, and colleagues conducted a prospective study involving 45,748 men and 196,357 women in the United States, free from CHD at baseline, who were participants in the Health Professionals Follow-up Study, and the Nurses’ Health Study I (NHS I) and NHS II. The correlation between a history of kidney stones and the risk of CHD was assessed.

The researchers found that 19,678 of the 242,105 participants reported a history of kidney stones. A total of 16,838 incident cases of CHD occurred after up to 24 years of follow-up in men and 18 years in women. Among women, those with a history of kidney stones had a significantly increased risk of CHD compared to those without a history (multivariable hazard ratios, 1.18 in NHS I and 1.48 in NHS II), after adjustment for potential confounders. Results were similar on analysis of individual end points (fatal and nonfatal myocardial infarction and revascularization).

“In conclusion, among two large cohorts of women, a history of kidney stones was associated with a modest but statistically significant increased risk of CHD; there was no significant association in a separate cohort of men,” the authors write.

Two authors disclosed financial ties to the pharmaceutical and medical device industries.

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