(HealthDay News) – Women with heart failure have a better prognosis than men, with the benefit more pronounced in non-ischemic heart failure and reduced by diabetes.

Manuel Martínez-Sellés, MD, of the Hospital General Universitario Gregorio Marañón in Madrid, and associates analyzed data from 31 studies involving 28,052 men and 13,897 women with heart failure to investigate the relationship between gender and survival.

During three years of follow-up, the researchers noted that 25% of women and 26% of men died. Male gender correlated with increased mortality. Improved prognosis for women was more marked in patients with heart failure that had non-ischemic etiology compared with ischemic etiology (P for interaction=0.03), and for those without diabetes vs those with diabetes (P for interaction <0.0001).

“This analysis from a large, individual patient data meta-analysis has demonstrated that women with heart failure have lower risk of death when compared with men with heart failure, in both preserved and reduced ejection fraction. This survival benefit may be more marked in heart failure of non-ischemic etiology but is clearly attenuated by concomitant diabetes,” the authors write. “Further study is required to determine the biological reasons for this better prognosis in women.”

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