(HealthDay News) – Nearly 20% of men with sexual dysfunction have impaired fasting glucose (IFG) and are more likely than men with normal glucose levels to have severe erectile dysfunction (ED), reduced penile blood flow, and overt hypogonadism as well as increased overall cardiovascular (CV) risk.

Giovanni Corona, MD, PhD, of the University of Florence in Italy, and colleagues conducted a retrospective study involving 3,451 men with sexual dysfunction to evaluate the impact of IFG on men’s sexual health. Glucose, testosterone (T), and other clinical and biochemical laboratory parameters were measured, and penile blood flow was assessed using Doppler ultrasound.

Among the participants, the researchers found that 21.7% had diabetes mellitus (DM) and 19.1% had IFG. Compared with men with normal glucose levels, those with IFG were more likely to exhibit severe ED, reduced penile blood flow, and overt hypogonadism. Men with IFG and ED tended to have an overall increased CV risk profile, including hypertension and dyslipidemia. Baseline DM was significantly associated with incidence of major adverse CV events, and there was a trend toward higher risk for IFG but it did not reach statistical significance. There was a higher risk of fatal and nonfatal cerebrovascular events for both DM and IFG.

“Checking glucose and T levels is mandatory in subjects with ED because T substitution in impotent IFG subjects might ameliorate not only their sexual life but also their overall health,” the authors write.

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