(HealthDay News) – Low serum concentrations of adiponectin prior to pregnancy may identify women at high risk for gestational diabetes mellitus (GDM), according to research published online Aug. 29 in Diabetes Care.

Monique Hedderson, PhD, of Kaiser Permanente Northern California in Oakland, and colleagues conducted a nested case-control study among women participating in the Kaiser Permanente Northern California Multiphasic Health Check-Up exam who had a subsequent pregnancy. Two controls matched by age and number of intervening pregnancies were selected for each of the 256 cases of women who developed GDM.

The researchers found that, after multivariable adjustment, the risk of GDM increased with decreasing quartile of serum adiponectin concentration (odds ratio [OR] and 95% confidence interval in descending order: 1.5 [0.7–2.9], 3.7 [1.9–7.2], and 5.2 [2.6–10.1]; Ptrend<0.001) compared with the highest quartile. Compared with normal-weight women with total adiponectin levels above the median, overweight or obese women with levels below the median were at increased risk for GDM (OR, 6.7).

“In summary, after adjusting for potential confounding factors and clinical factors known to be related to insulin resistance, we found that low adiponectin concentrations, measured on average six years prior to pregnancy, were associated with a five-fold increased risk of GDM,” the authors write.

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