(HealthDay News) – After adjustment, implant failure is more likely for women than men who undergo total hip arthroplasty (THA), according to a study published online Feb. 18 in JAMA Internal Medicine.

Maria C. S. Inacio, from Southern California Permanente Medical Group in San Diego, and colleagues conducted a prospective evaluation of a cohort of patients undergoing primary, elective, unilateral THA, enrolled in a total joint replacement registry from April 2001, through December 2010. The patients (mean age, 65.7 years; 57.5% women) underwent 35,140 THAs, with a median follow-up of 3 years.

The researchers found that a higher proportion of women than men received 28-mm femoral heads (28.2% vs. 13.1%) and had metal on highly cross-linked polyethylene-bearing surfaces (60.6% vs. 53.7%); whereas a higher proportion of men than women had 36-mm or larger heads (55.4% vs. 32.8%) and metal on metal-bearing surfaces (19.4% vs. 9.6%). Implant survival was 97.4% at five-year follow-up. In men, device survival was significantly higher than in women (97.7% vs. 97.1%; P=0.01). After adjustment, women had a significantly increased risk of all-cause revision (hazard ratio, 1.29), aseptic revision (hazard ratio, 1.32), and an increased risk of septic revision (hazard ratio, 1.17; 95% confidence interval, 0.81–1.68).

“After considering patient-, surgery-, surgeon-, volume-, and implant-specific risk factors, women had a 29% higher risk of implant failure than men after THA in this community-based sample,” write the authors.

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