JAMA Dermatology: High-Dose Isotretinoin Treatment and the Rate of Retrial, Relapse, and Adverse Effects in Patients With Acne Vulgaris. Rachel C. Of these, 116 participated in the 12-month follow-up survey, for a response rate of 64.4%. Exposure Patients received isotretinoin, with dosing based on the providers’ judgment.

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