(HealthDay News) — Among individuals with diabetes, women have a substantially greater risk of developing coronary heart disease (CHD) than men, according to research published online May 22 in Diabetologia.

Sanne A.E. Peters, PhD, of the University Medical Center Utrecht in the Netherlands, and colleagues conducted a systematic review of the literature and a meta-analysis of 64 cohorts involving 858,507 individuals and 28,203 coronary events. The researchers examined the sex-specific effect of diabetes on incident CHD.

The researchers found that the risk of incident CHD among individuals with diabetes, compared with those without diabetes, was higher in women (relative risk [RR], 2.82; 95% confidence interval [CI], 2.35–3.38) than in men (RR, 2.16; 95% CI, 1.82–2.56). Women with diabetes had a 44% greater multiple-adjusted RR ratio (RRR) for CHD than men with diabetes (RRR, 1.44; 95% CI, 1.27–1.63), with no significant heterogeneity noted between studies.

“Further studies are warranted to determine the actual mechanisms responsible for the difference in diabetes-related coronary risk between the sexes,” the authors write.

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