Diabetes, Cardiac Risk Up for Metabolically Healthy Obese

Positive Predictive Value of Treadmill Test Varies in Women
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Risk of incident diabetes, cardiovascular disease also up for metabolically unhealthy normal weight.

(HealthDay News) – Metabolically healthy obese (MHO) and metabolically unhealthy normal weight (MUH-NW) individuals have increased risks of developing type 2 diabetes mellitus (DM) and cardiovascular disease (CVD), according to a study published online Nov. 20 in the Journal of Clinical Endocrinology & Metabolism.

KoKo Aung, MD, MPH, from the University of Texas Health Science Center in San Antonio, and colleagues utilized data from the population-based San Antonio Heart Study involving Mexican Americans and non-Hispanic whites, followed for a median of 7.4 years to assess incident DM and CVD in 2,814 and 3,700 participants (aged 25–64 years), respectively. MHO was defined as obesity (body mass index [BMI] ≥30kg/m²) with one or no metabolic abnormalities; and MUH-NW was defined as BMI <25kg/m² with two or more metabolic abnormalities.

The researchers found that after controlling for demographic factors, family DM history, and fasting glucose, BMI correlated with incident DM (odds ratio, 1.7). The risk of DM was increased among MUH-NW (odds ratio, 2.5) and MHO individuals (odds ratio, 3.9). After adjustment for demographics and Framingham risk scores, BMI was also related to incident CVD (odds ratio, 1.3). MUH-NW and MHO individuals had increased odds of incident CVD (odds ratios, 2.9 and 3.9, respectively).

“Screening for obesity and other metabolic abnormalities should be routinely performed in clinical practice to institute appropriate preventive measures,” the authors conclude.

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