Depression May Worsen Kidney Disease in Diabetes Patients

(HealthDay News) — Patients with diabetes who have comorbid major depression may be at greater risk of end-stage renal disease (ESRD), according to research published online March 27 in the Clinical Journal of the American Society of Nephrology.

Margaret K. Yu, MD, of the University of Washington in Seattle, and colleagues followed 3,886 ambulatory adults with diabetes in a prospective cohort for a median of 8.8 years to assess the association between depressive symptoms and risk of incident ESRD.

The researchers found that 87 patients (2.2%) developed ESRD. After adjustment for multiple variables, including age, sex, race/ethnicity, smoking, body mass index, baseline kidney function, hypertension, and diabetes-related characteristics, major depressive symptoms were found to be associated with an increased risk of incident ESRD (hazard ratio [HR], 1.85; 95% confidence interval [CI], 1.02–3.33). The association between minor depressive symptoms and incident ESRD was not significant (HR, 1.08; 95% CI, 0.52–2.25).

“Major depressive symptoms, but not minor depressive symptoms, were associated with a higher risk of incident ESRD over up to 10 years,” the authors write. “Additional studies are needed to determine whether treatment for depression can improve renal outcomes in patients with diabetes.”

One author disclosed financial ties to the pharmaceutical industry.

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