(HealthDay News) – Abnormal levels of cerebrospinal fluid biomarkers Aβ42 and phosphorylated tau181 are associated with decreased functional connectivity in the default mode network prior to clinical onset of Alzheimer’s disease, according to a study published online Aug. 19 in JAMA Neurology.

Liang Wang, MD, from Washington University in St. Louis, and colleagues studied 207 older adults with normal cognition using resting-state functional connectivity magnetic resonance imaging measures of default mode network integrity.

The researchers observed an independent association between decreased cerebrospinal fluid Aβ42 and increased cerebrospinal fluid phosphorylated tau181 and reduced default mode network integrity. The most prominent decreases in functional connectivity were observed between the posterior cingulate and medial temporal regions. These reductions in functional connectivity were not attributable to age or structural atrophy in those brain regions.

“Both Aβ and tau pathology affect default mode network integrity before clinical onset of Alzheimer’s disease,” the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

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