(HealthDay News) — For patients with thyroid eye disease (TED), a contact lens sensor provides a safe and well-tolerated approach for 24-hour intraocular pressure (IOP) monitoring, according to a study published in the March issue of Clinical & Experimental Ophthalmology.

Anjali S. Parekh, MD, from the University of California in San Diego, and colleagues conducted a prospective study in 10 patients with established TED (mean age, 61.8 years; 90% female) to examine the safety, tolerability, and 24-hour IOP patterns using a contact lens sensor. The authors assessed the incidence of adverse events and tolerability (scale of 0 to 10, increasing intolerance); a cosinor rhythmometry model was used to assess IOP patterns.

The researchers found that the main adverse events were blurred vision, conjunctival hyperemia, and superficial punctate keratitis (50, 100, and 20%, respectively). The lens tolerability was found to be 1.5 ± 0.7. Using a contact lens sensor signal, positive linear slopes were detected from wake to sleep (P=0.254), whereas there was a significant decrease at the transition from sleep/supine to wake/sitting (P=0.010). A significant nocturnal/sleep acrophase was seen in five patients, with the peak occurring at 6:30 a.m. The 24-hour curves had a mean amplitude of 102.2 ± 52.6 a.u.

“The contact lens sensor provides a safe and well-tolerated approach to 24-hour IOP monitoring,” the authors write.

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Several authors disclosed financial ties to medical device companies, including Sensimed AG, which funded the study.

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