Methods and Results- A matched cohort study was implemented in the UK Clinical Practice Research Datalink (CPRD) including participants with severe psoriasis (5,648), mild psoriasis (85,232), bullous skin diseases (4,284), ulcerative colitis (12,203), Crohn’s disease (7,628), inflammatory arthritis (27,358), systemic autoimmune disorders (7,472), systemic vasculitis (6,283) and 373,851 matched controls.

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