Importance: Certain antimicrobial drugs interact with sulfonylureas to increase the risk of hypoglycemia. Design, Setting, and Participants: This was a retrospective cohort study of Texas Medicare claims from 2006–2009 for patients 66 years or older who were prescribed glipizide or glyburide and who also filled a prescription for one of the 16 antimicrobials most commonly prescribed for this population.

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