Cardiopulmonary Exercise Tests Provide Strong Predictor of Mortality in HFrEF

HealthDay News — Variables measured during a cardiopulmonary exercise (CPX) test can predict and discriminate mortality in patients with heart failure with reduced ejection fraction (HFrEF), according to a study published in the February 23 issue of the Journal of the American College of Cardiology.

Steven J. Keteyian, PhD, from the Henry Ford Hospital in Detroit, and colleagues report on the strength of the association among variables measured during a CPX test and all-cause mortality in patients with HFrEF. Ten CPX test variables were measured at baseline among 2,100 patients enrolled in the Heart Failure-A Controlled Trial Investigating Outcomes of Exercise Training.

The researchers identified 357 deaths over a median follow-up of 32 months. With the exception of respiratory exchange ratio, all CPX variables correlated with all-cause mortality (P < 0.0001). Percent predicted peak oxygen uptake (ppVo2) and exercise duration were able to predict and discriminate mortality equally (c-index, 0.69). Among men and women, respectively, the strongest predictor of mortality was peak Vo2 and exercise duration. Percent ppVo2, exercise duration, and peak Vo2 were similarly able to predict and discriminate mortality, in multivariable analyses. A 10 percent one-year mortality rate corresponded to peak Vo2 of 10.9 ml/kg−1/min−1 in men versus 5.3 ml/kg−1/min−1 in women.

“Peak Vo2, exercise duration, and percent ppVo2 carried the strongest ability to predict and discriminate the likelihood of death in patients with HFrEF,” the authors write. “The prognosis associated with a given peak Vo2 differed by sex.”

One author disclosed financial ties to Merck Research Laboratories.

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