(HealthDay News) — More patients with nonceliac wheat sensitivity (NCWS) and celiac disease (CD) than irritable bowel syndrome (IBS) develop autoimmune diseases (ADs), according to a study published in the September issue of Gastroenterology.
Antonio Carroccio, MD, from the University of Palermo in Italy, and colleagues conducted a retrospective study of 131 patients with NCWS and 151 control patients with CD and IBS to examine the prevalence of AD and antinuclear antibodies (ANA). A prospective study was conducted involving 42 patients with NCWS and 100 age- and sex-matched controls with CD or IBS.
The researchers found that 29% of patients with NCWS and CD developed ADs (mainly Hashimoto’s thyroiditis) compared to 4% of patients with IBS (P<0.001). In the prospective study, 24, 20, and 2%, respectively, developed ADs (P<0.001). Serum samples tested positive for ANA in 46, 24, and 2% of samples with NCWS, CD, and IBS, respectively (P<0.001 for CD and IBS vs. NCWS), in the retrospective study. The corresponding values in the prospective study were 28, 7.5, and 6% (P=0.02 for CD and P=0.005 for IBS vs. NCWS).
“Higher proportions of patients with NCWS or CD develop autoimmune disorders, are ANA positive, and showed DQ2/DQ8 haplotypes compared with patients with IBS,” the authors write.