(HealthDay News) – The rising incidence of anal cancer since 1980 in the United States is strongly impacted by HIV infection in men but not women, according to a study published online Oct 5 in the Journal of the National Cancer Institute.

Meredith S Shiels, PhD, MHS, from the National Cancer Institute in Rockville, MD, and colleagues analyzed data on HIV incidence and anal cancer from the HIV/AIDS Cancer Match Study from 1980–2005.

Of 20,533 estimated anal cancer cases during this period, the researchers found that 8.1% were infected with HIV. From 2001–2005, the highest proportion of anal cancer cases with HIV infection were seen — 1.2% of women and 28.4% of men. From 1980–2005, HIV infection had no impact on the increasing anal cancer incidence in women, which increased by 3.3% annually, independent of HIV infection. For men, HIV infection strongly influenced the incidence of anal cancer, which increased by 3.4% annually overall and by 1.7% annually without HIV infection.

“During 1980–2005, the increasing anal cancer incidence rates in the United States were strongly influenced by the HIV epidemic in males but were independent of HIV infection in females,” Shiels and colleagues conclude.

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