(HealthDay News) — For patients with left breast cancer, radiation therapy with the Active Breathing Coordinator (ABC) can reduce the mean heart dose (MHD) by ≥20%, while preserving local control, according to a study published in the January-February issue of Practical Radiation Oncology.

Harriet Eldredge-Hindy, MD, from Thomas Jefferson University in Philadelphia, and colleagues conducted a prospective trial to examine whether radiation therapy with ABC can reduce the MHD by ≥20% in patients with stages 0 to III left breast cancer. One hundred twelve patients were enrolled and 86 underwent simulation with free breathing and ABC for comparison of dosimetry. If the MHD was reduced by ≥5%, ABC was used during the patent’s radiation therapy course.

The researchers found that 81 patients received radiation therapy using ABC, representing 72% procedural success. Use of ABC reduced MHD by ≥20% in 88 percent of patients, representing achievement of the primary end point (P<0.0001). The median value for absolute reduction in MHD was 1.7 Gy, and relative reduction was 62%. There was a significant dose reduction to the left lung with radiation therapy with ABC. Eight-year estimates of locoregional relapse, disease-free survival, and overall survival were 7, 90, and 96%, respectively.

“ABC was well tolerated and significantly reduced MHD while preserving local control,” the authors write.

Full Text