(HealthDay News) – Maternal history of migraine is significantly associated with an increased risk of infant colic, according to a study being released in advance of its presentation at the annual meeting of the American Academy of Neurology, held from April 21–28 in New Orleans.

Amy Gelfand, MD, from the University of California in San Francisco, and colleagues surveyed mothers at their infants’ 2-month-old well-child visit. Parents reported on colic using the modified Wessel’s colic criteria. Having a physician diagnosis or a positive screen on IDMigraine was indicative of migraine history. The difference in colic prevalence in infants with or without a maternal history of migraine was the primary outcome measure.

The investigators found that, based on data from 154 infant-mother pairs, infants with a maternal history of migraine were significantly more likely to have colic than those without maternal history of migraine (28.6% vs. 11.1%; prevalence ratio, 2.6; P=0.02). Based on data from 93 infant-father pairs, infants with a paternal history of migraine had a trend toward increased prevalence of colic (22.2% vs. 9.5%; prevalence ratio, 2.3; P=0.24).

“Maternal migraine is associated with increased risk of infant colic. As migraine has a strong genetic underpinning, this association suggests that infant colic may be an early life manifestation of migraine,” the authors write.

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