(HealthDay News) – Increased caloric intake is associated with increased odds of mild cognitive impairment (MCI) in elderly adults, according to a study being released in advance of its presentation at the annual meeting of the American Academy of Neurology, which will be held from April 21–28 in New Orleans.
Yonas E. Geda, MD, from the Mayo Clinic in Scottsdale, AZ, and colleagues investigated the association between daily energy consumption and MCI. A random sample of 1,233 older adults (aged 70–89 years), including 1,070 cognitively normal individuals and 163 with MCI, reported their caloric consumption. Participants were classified by their responses according to tertiles of caloric intake (600 to <1,526 kcal/day [lowest tertile and reference group], 1,526 to 2,142.5 kcal/day [middle tertile], and >2,142.5 to 6,000 kcal/day [highest tertile]).
The investigators found that, in the primary analysis, there was no significant difference between the middle tertile and the reference group after adjusting for confounding variables (odds ratio [OR], 1.05; 95% CI, 0.63–1.77; P=0.84). Daily energy consumption in the highest tertile correlated with significantly increased odds of having MCI (OR, 2.41; 95% CI, 1.51–3.86). A dose-response pattern was observed, with increasing likelihood of MCI with increasing caloric consumption (P for trend < 0.001).
“In this population-based case-control study, increased caloric intake was associated with increased odds of having MCI,” the authors write.