(HealthDay News) – For patients with HIV-1 infection and HIV-1 RNA of >1,000 copies/mL, treatment with dolutegravir plus abacavir-lamivudine (DTG-ABC-3TC) is more effective through 48 weeks than combination therapy with efavirenz-tenofovir disoproxil fumarate (DF)-emtricitabine (EFV-TDF-FTC), according to a study published in the Nov. 7 issue of the New England Journal of Medicine.
Sharon L. Walmsley, MD, from the University Health Network in Toronto, and colleagues conducted a randomized, double-blind, Phase 3 study involving 833 treatment-naive adult participants with an HIV-1 RNA level of >1,000 copies/mL. Participants were randomly allocated to receive DTG-ABC-3TC or combination therapy with EFV-TDC-FTC.
The researchers found that the proportion of patients with an HIV-1 RNA level of <50 copies/mL was significantly higher in the DTG-ABC-3TC group (88%) than in the EFV-TDF-FTC group (81%) at Week 48, meeting the criteria for superiority. The median time to viral suppression was shorter in the DTG-ABC-3TC group, and there were greater increases in the CD4+ T-cell count than with EFV-TDF-FTC. A lower proportion of patients in the DTG-ABC-3TC group discontinued therapy because of adverse events.
“Dolutegravir plus abacavir-lamivudine had a better safety profile and was more effective through 48 weeks than the regimen with efavirenz-tenofovir DF-emtricitabine,” the authors write.
The study was funded by ViiV Healthcare, the manufacturer and/or marketer of dolutegravir and abacavir-lamivudine.