HealthDay News — For chronic migraine, botulinum type A injections are superior to placebo after 3 months of therapy, according to a meta-analysis published in the January issue of Plastic and Reconstructive Surgery.

Eva Bruloy, MD, from the University Hospital of Picardie in France, and colleagues conducted a systematic literature review and meta-analysis to compare patients receiving botulinum toxin to those receiving placebo injections in the head and neck muscles for the preventive treatment of migraine. Data were included from 17 studies involving 3646 patients.

At 3 months, the researchers found a tendency in favor of botulinum toxin over placebo, with a mean difference in the change of migraine frequency of −0.23 (95% confidence interval, −0.47 to 0.02; P=.08). There was a significant reduction in the frequency of chronic migraines, with a mean differential change of −1.56 (95% confidence interval, −3.05 to −0.07; P=.04). After 2 months, the analysis of chronic migraine frequency was also significant. At 3 months, the botulinum group had significant improvement in patient quality of life (P<.00001). The investigators noted a statistically significant risk ratio of 1.32 for adverse events in the botulinum group (P=.002). 

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“Botulinum toxin type A is a safe and well-tolerated treatment that should be offered to patients with migraine,” the authors write.

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