Psoriasis patients, regardless of disease severity, may be at an increased risk of depression, according to a study recently published in JAMA Dermatology.

Roger S. Ho, MD, MS, MPH, from the New York University School of Medicine, and colleagues analyzed data from the National Health and Nutrition Examination Survey (NHANES) spanning 2009–2012 on rates of psoriasis and depression. A total of 16.5% patients with psoriasis met the criteria for a diagnosis of major depression and Mean Patient Health Questionnaire-9 scores were significantly higher among patients with a history of psoriasis compared to those without. Risk of psoriasis was significantly associated with major depression even after adjusting for sex, age, race, body mass index, physical activity, smoking history, alcohol use, and history of myocardial infarction, stroke, or diabetes.

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Depression risk was not different between patients with limited compared to extensive psoriasis. In patients with psoriasis, a history of cardiovascular events did not affect the risk of major depression. More patients with psoriasis reported that any symptoms of depression caused daily functional impairment compared to those without psoriasis.

The authors concluded that all patients with psoriasis, regardless of severity, may benefit from depression screening.

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