A study published in Arthritis & Rheumatology has found that the DASH diet reduced serum uric acid, particularly in patients with hyperuricemia.
Currently, there is not much evidence to guide dietary recommendations for lowering serum uric acid. Researchers from Johns Hopkins University School of Medicine studied the effects of the DASH diet and levels of sodium intake on serum uric acid. They conducted an ancillary study of a randomized, cross-over feeding trial (n=103) in adults with pre- or stage 1 hypertension. Study patients were randomized to either receive the DASH diet or a control diet (average American diet), and were additionally given low, medium, andhigh sodium levels for 30 days each in random order. Serum uric acid levels were measured at baseline and after each feeding period.
At baseline, patients had a mean serum uric acid of 5.0mg/dL. Patients given the DASH diet had a reduction in serum uric acid by –0.35mg/dL (95% CI: –0.65, –0.05; P=0.02) with a greater effect seen in the 8 patients with baseline serum uric acid ≥7.0mg/dL (–1.3mg/dL, 95% CI: –2.5, –0.08).
Increasing the intake of sodium from the low level was shown to decrease serum uric acid by –0.3mg/dL (95% CI: –0.5, –0.2; P<0.001) and –0.4mg/dL (95% CI: -0.6, -0.3; P<0.001) during the medium and high sodium level, respectively.
Study authors concluded that the DASH diet may be an effective, non-pharmacologic way to prevent gout flares. The DASH diet decreased serum uric acid levels more profoundly among patients with hyperuricemia; higher sodium intake also decreased serum uric acid levels, adding more insight into urate pathophysiology and risk factors for hyperuricemia.
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