For overweight or obese black patients, the current recommendation on the minimum daily dose of vitamin D is insufficient to restore healthy levels, according to a study. Findings of the study are published in BioMed Central Obesity.
Currently, the Institute of Medicine (IOM) recommends 600 IU for most children and adults and 800 IU for adults ≥70 years; the upper daily limit is recommended at 4,000 IU. Researchers from the Medical College of Georgia evaluated the effects of three levels of vitamin D supplementation in overweight-to-obese black patients (n=70) under 50 years old in the Southeastern U.S. who appeared healthy but had low circulating vitamin D levels.
They found that more than triple the recommended daily minimum was needed to restore a healthy blood level of vitamin D. The recommended 600 IUs did not result in the optimal blood level of vitamin D in 16 weeks. However, the current 4,000 IU upper limit and previous 2,000 IU upper limit did restore the desired 30ng/mL level in individuals with previous levels of <20ng/mL. The 4,000 IU upper limit dose restored blood levels earlier by eight weeks and more effectively suppressed parathyroid hormone. For patients in the study, those with high parathyroid hormone levels achieved the desired results with a 4,000 IU/day dose, while others achieved optimal levels with the 2,000 IU/day dose.
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