HealthDay News – For patients with moderate-to-severe COVID-19, colchicine reduces the length of supplemental oxygen therapy and hospitalization, according to a study published online February 4 in RMD Open.
Maria Isabel Lopes, from the University of São Paulo in Brazil, and colleagues present the results of a randomized, double-blind, placebo-controlled clinical trial of colchicine for treatment of moderate-to-severe COVID-19. A total of 72 patients were randomly assigned to either colchicine (0.5mg 3 times daily for 5 days then twice daily for 5 days) or placebo (36 patients in each group).
The researchers found that the median time of need for supplemental oxygen was 4.0 and 6.5 days for the colchicine and placebo groups, respectively. The median time of hospitalization was 7.0 and 9.0 days for the colchicine and placebo groups, respectively. At day 2, 67 and 86% of patients in the colchicine and placebo groups, respectively, maintained the need for supplemental oxygen, while at day 7, the values were 9 and 42%, respectively. There were 2 deaths, both in the placebo group. Diarrhea occurred more often in the colchicine group.
“Whatever the mechanism of action, inhibiting inflammasome, reducing neutrophil migration and activation or preventing endothelial damage, colchicine seems to be beneficial for the treatment of hospitalized patients with COVID-19,” the authors write.