HealthDay News — No concerning associations are seen for measures of the recommended immunization schedule with type 1 diabetes mellitus (T1DM) among children, according to a study published online November 9 in Pediatrics.

Jason M. Glanz, PhD, from Kaiser Permanente Colorado in Denver, and colleagues examined the correlation between the recommended immunization schedule and T1DM in a retrospective cohort study of children born between 2004 and 2014. Average days undervaccinated (ADU), cumulative antigen exposure, and cumulative aluminum exposure were examined as measures of the immunization schedule. The correlations between these measures and T1DM incidence were analyzed.

The researchers found that the mean ADU was 38 days, the mean cumulative antigen exposure was 263 antigens, and the mean cumulative aluminum exposure was 4.11mg in a cohort of 584,171 children. A total of 1132 incident cases of T1DM were identified. There was no association seen for ADU (adjusted hazard ratio, 1.01; 95% CI, 0.99 to 1.02) or cumulative antigen exposure (adjusted hazard ratio, 0.98; 95% CI, 0.97 to 1.00) with T1DM. An inverse association was seen for cumulative aluminum exposure greater than 3.00mg with T1DM (adjusted hazard ratio, 0.77; 95% CI, 0.60 to 0.99).

“To maintain public trust in the US childhood immunization program, in future studies, researchers should also continue to examine the safety of the entire recommended immunization schedule relative to other health conditions that concern the public,” the authors write.

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